Regulatory polymorphisms in the cyclophilin A gene, PPIA, accelerate progression to AIDS.

Regulatory polymorphisms in the cyclophilin A gene, PPIA, accelerate progression to AIDS.

Human cyclophilin A, or CypA, encoded by the gene peptidyl prolyl isomerase A (PPIA), is incorporated into the HIV type 1 (HIV-1) virion and promotes HIV-1 infectivity by facilitating virus uncoating. We examined the effect of single nucleotide polymorphisms (SNPs) and haplotypes within the PPIA gen...

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Main Authors: Ping An, Li Hua Wang, Holli Hutcheson-Dilks, George Nelson, Sharyne Donfield, James J Goedert, Charles R Rinaldo, Susan Buchbinder, Gregory D Kirk, Stephen J O'Brien, Cheryl A Winkler
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2007-06-01
Series:PLoS Pathogens
Online Access:https://journals.plos.org/plospathogens/article/file?id=10.1371/journal.ppat.0030088&type=printable
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https://journals.plos.org/plospathogens/article/file?id=10.1371/journal.ppat.0030088&type=printable

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