Methionine Aminopeptidase 2 (MetAP2) Inhibitor BL6 Attenuates Inflammation in Cultured Microglia and in a Mouse Model of Alzheimer’s Disease

Methionine Aminopeptidase 2 (MetAP2) Inhibitor BL6 Attenuates Inflammation in Cultured Microglia and in a Mouse Model of Alzheimer’s Disease

Methionine aminopeptidase 2 (MetAP2) plays an important role in the regulation of protein synthesis and post-translational processing. Preclinical/clinical applications of MetAP2 inhibitors for the treatment of various diseases have been explored because of their antiangiogenic, anticancer, antiobes...

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Bibliographic Details
Main Authors: Xiuli Zhang, Shivakumar Subbanna, Colin R. O. Williams, Stefanie Canals-Baker, Audrey Hashim, Donald A. Wilson, Louis M. Weiss, Srushti Shukla, Parthiban Chokkalingam, Sasmita Das, Bhaskar C. Das, Mariko Saito
Format: Article
Language:English
Published: MDPI AG 2025-01-01
Series:Molecules
Subjects:
MetAP2 inhibitors
microglia
neuroinflammation
SIM-A9
icv-STZ
Alzheimer’s disease
Online Access:https://www.mdpi.com/1420-3049/30/3/620
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