Lower Frequency of PNPLA3 Polymorphism in West African Populations and Divergent Associations With Hepatocellular Carcinoma

Lower Frequency of PNPLA3 Polymorphism in West African Populations and Divergent Associations With Hepatocellular Carcinoma

Background and Aims: The germline variant patatin-like phospholipase domain-containing protein 3 (PNPLA3)-rs738409 (I148M) is associated with a higher risk of hepatocellular carcinoma (HCC) in European and East Asian populations, but its association with HCC in Africans has not been investigated. We...

Full description

Saved in:
Bibliographic Details
Main Authors: Perapa Chotiprasidhi, Yvonne Ayerki Nartey, Karina Sato-Espinoza, Robert A. Vierkant, Jun Ma, Yaw Awuku, Adwoa Agyei-Nkansah, Mary Afihene, Amoako Duah, Sally Bampoh, Shadrack Asibey, Joshua Ayawin, Jun Wang, Yinan Zheng, Lifang Hou, Claudia Hawkins, Robert Murphy, Godwin Imade, Edith Okeke, Alani Akanmu, Olufunmilayo Lesi, Amelie Plymoth, Jose D. Debes, Lewis R. Roberts, Samuel O. Antwi, Kirk J. Wangensteen
Format: Article
Language:English
Published: Elsevier 2025-01-01
Series:Gastro Hep Advances
Subjects:
Disparity
Genetic Association Study
Polygenic Risk Score
Genetic Ancestry
Online Access:http://www.sciencedirect.com/science/article/pii/S2772572325000263
Tags: Add Tag
No Tags, Be the first to tag this record!

Internet

http://www.sciencedirect.com/science/article/pii/S2772572325000263

Similar Items