FLT4 activation promotes acute lymphoid leukemia survival through stabilization of MDM2/MDMX and inactivation of p53

FLT4 activation promotes acute lymphoid leukemia survival through stabilization of MDM2/MDMX and inactivation of p53

Abstract Aberrant Receptor Tyrosine Kinase (RTK) signaling allows cancer cells to modulate survival, proliferation, and death, leading to tumorigenesis and chemoresistance. In leukemia, the RTK FMS-Related Tyrosine Kinase 4 (FLT4) (also known as VEGFR3, Vascular Endothelial Growth Factor Receptor- 3...

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Main Authors: Djazia Haferssas, Marion Dubuissez, Jonatan Barrera-Chimal, Clémence Messmer, El Bachir Affar, Bruno Larrivée, Xue-Song Liu, Casimiro Gerarduzzi
Format: Article
Language:English
Published: Nature Publishing Group 2025-05-01
Series:Oncogenesis
Online Access:https://doi.org/10.1038/s41389-025-00552-7
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https://doi.org/10.1038/s41389-025-00552-7

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