Plasma biomarkers for afatinib monotherapy in EGFR-mutated non-small cell lung cancer: Novel insights from companion genomics analysis of the EXTRA study

Plasma biomarkers for afatinib monotherapy in EGFR-mutated non-small cell lung cancer: Novel insights from companion genomics analysis of the EXTRA study

Objectives: Plasma-based testing with circulating cell-free DNA (cfDNA) is an active area of biomarker exploratory studies in patients with non-small cell lung cancer (NSCLC) harboring EGFR mutations. The Exosome-focused Translational Research for Afatinib study prospectively explored novel plasma b...

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Main Authors: Tomonori Makiguchi, Hisashi Tanaka, Kei Morikawa, Aya Hirata, Hidetoshi Itani, Shigeru Tanzawa, Kageaki Watanabe, Hiroyuki Yasuda, Kazuya Horiuchi, Hideyuki Nakagawa, Yoshitaka Seki, Yoshiro Nakahara, Kentaro Hayashi, Nobumasa Takahashi, Takeo Endo, Akihiro Bessho, Tetsuya Okano, Kiyoshi Takeyama, Akikazu Kawase, Makoto Endo, Toshiya Maekura, Kenji Nemoto, Nagio Takigawa, Kazuma Kishi, Kenzo Soejima, Yusuke Okuma, Akira Togashi, Noriyuki Matsutani, Hiroki Shinchi, Koji Ueda, Nobuhiko Seki
Format: Article
Language:English
Published: Elsevier 2025-01-01
Series:Cancer Treatment and Research Communications
Subjects:
Plasma biomarker
Cell-free DNA
Extracellular vesicle-derived DNA
Non-small cell lung cancer
Afatinib
Online Access:http://www.sciencedirect.com/science/article/pii/S2468294225000887
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