Lovastatin Decreases the Expression of CD133 and Influences the Differentiation Potential of Human Embryonic Stem Cells

Lovastatin Decreases the Expression of CD133 and Influences the Differentiation Potential of Human Embryonic Stem Cells

The lipophilic statin lovastatin decreases cholesterol synthesis and is a safe and effective treatment for the prevention of cardiovascular diseases. Growing evidence points at antitumor potential of lovastatin. Therefore, understanding the molecular mechanism of lovastatin function in different cel...

Full description

Saved in:

Bibliographic Details
Main Authors:	Ade Kallas-Kivi, Annika Trei, Toivo Maimets
Format:	Article
Language:	English
Published:	Wiley 2016-01-01
Series:	Stem Cells International
Online Access:	http://dx.doi.org/10.1155/2016/1580701
Tags:	Add Tag No Tags, Be the first to tag this record!

Similar Items

SOX2 Is Regulated Differently from NANOG and OCT4 in Human Embryonic Stem Cells during Early Differentiation Initiated with Sodium Butyrate
by: Ade Kallas, et al.
Published: (2014-01-01)

CD133 Antigen as a Potential Marker of Melanoma Stem Cells: In Vitro and In Vivo Studies
by: Tomasz Kloskowski, et al.
Published: (2020-01-01)

Enhanced Expression of ABCB1 and Nrf2 in CD133-Positive Cancer Stem Cells Associates with Doxorubicin Resistance
by: Shinji Goto, et al.
Published: (2020-01-01)

Combined prognostic value of the cancer stem cell markers CD47 and CD133 in esophageal squamous cell carcinoma
by: Jian‐Hua Wang, et al.
Published: (2019-03-01)

Differences Between Lovastatin and Simvastatin Hydrolysis in Healthy Male and Female Volunteers: Gut Hydrolysis of Lovastatin is Twice that of Simvastatin
by: Tom B. Vree, et al.
Published: (2003-01-01)

Unveiling the impact of CD133 on cell cycle regulation in radio- and chemo-resistance of cancer stem cells
by: Luyao Wu, et al.
Published: (2025-02-01)

Alteration of Differentiation Potentials by Modulating GATA Transcription Factors in Murine Embryonic Stem Cells
by: Callinice D. Capo-chichi, et al.
Published: (2010-01-01)

Changes in the Expression of Mitochondrial Morphology-Related Genes during the Differentiation of Murine Embryonic Stem Cells
by: Jeong Eon Lee, et al.
Published: (2020-01-01)

Mechanisms Regulating Stemness and Differentiation in Embryonal Carcinoma Cells
by: Gregory M. Kelly, et al.
Published: (2017-01-01)

Detection of the Hematopoietic Stem and Progenitor Cell Marker CD133 during Angiogenesis in Three-Dimensional Collagen Gel Culture
by: Masumi Akita, et al.
Published: (2013-01-01)

Absence of Rybp Compromises Neural Differentiation of Embryonic Stem Cells
by: Gergo Kovacs, et al.
Published: (2016-01-01)

Differentiation of Human Embryonic Stem Cells to Sympathetic Neurons: A Potential Model for Understanding Neuroblastoma Pathogenesis
by: Jane Carr-Wilkinson, et al.
Published: (2018-01-01)

Differentiation of Human Embryonic Stem Cells into Neuron, Cholinergic, and Glial Cells
by: Kimia Hosseini, et al.
Published: (2020-01-01)

IMPACT-CABG Trial: Implantation of CD133+ Stem Cells in Patients Undergoing Coronary Bypass Surgery—Presentation of the First Treated Patient
by: Jessica Forcillo, et al.
Published: (2011-01-01)

Prominosomes - a particular class of extracellular vesicles containing prominin-1/CD133?
by: Jana Karbanová, et al.
Published: (2025-01-01)

Influence of the Preparation Method on Some Characteristics of Alginate/Chitosan/Lovastatin Composites
by: Duc-Thuan Nghiem, et al.
Published: (2020-01-01)

BMI1, ALDH1A1, and CD133 Transcripts Connect Epithelial-Mesenchymal Transition to Cancer Stem Cells in Lung Carcinoma
by: Ana Koren, et al.
Published: (2016-01-01)

Transcription Factor Lbx1 Expression in Mouse Embryonic Stem Cell-Derived Phenotypes
by: Stefanie Schmitteckert, et al.
Published: (2011-01-01)

MOUSE AND HUMAN EMBRYONIC STEM CELLS
by: A. G. Menzorov
Published: (2014-12-01)

Effects of Aminoglycoside Antibiotics on Human Embryonic Stem Cell Viability during Differentiation In Vitro
by: Divya S. Varghese, et al.
Published: (2017-01-01)

Tumorigenic and Differentiation Potentials of Embryonic Stem Cells Depend on TGFβ Family Signaling: Lessons from Teratocarcinoma Cells Stimulated to Differentiate with Retinoic Acid
by: Olga Gordeeva, et al.
Published: (2017-01-01)

Efficient and Fast Differentiation of Human Neural Stem Cells from Human Embryonic Stem Cells for Cell Therapy
by: Xinxin Han, et al.
Published: (2017-01-01)

Comparison of Gene Expression in Human Embryonic Stem Cells, hESC-Derived Mesenchymal Stem Cells and Human Mesenchymal Stem Cells
by: Romain Barbet, et al.
Published: (2011-01-01)

Shell Model Calculations of Energy Levels and Binding Energy of 133;135Sn, and 133;135Sb Nuclei
by: Ruaa S. Abdullhussein
Published: (2022-03-01)

Electroporation of mouse embryonic stem cells with Neon device
by: I. P. Savchenkova, et al.
Published: (2022-09-01)

Alternative Splicing in Self-Renewal of Embryonic Stem Cells
by: Clara Y. Cheong, et al.
Published: (2011-01-01)

Laminin 521 Stabilizes the Pluripotency Expression Pattern of Human Embryonic Stem Cells Initially Derived on Feeder Cells
by: Halima Albalushi, et al.
Published: (2018-01-01)

Impact of Light and Temperature on Growth, Intracellular and Extracellular Pigment, and Lovastatin Yield by Monascus ruber in Synthetic Medium
by: K. Suganya, et al.
Published: (2022-01-01)

CD133+PD-L1+ cancer cells confer resistance to adoptively transferred engineered macrophage-based therapy in melanoma
by: Jiaojiao Xu, et al.
Published: (2025-01-01)

CD4 expression controls epidermal stem cell balance
by: Nadine Brandes, et al.
Published: (2025-02-01)

Decreased Expression of CD14 in MSU-Mediated Inflammation May Be Associated with Spontaneous Remission of Acute Gout
by: Lihua Duan, et al.
Published: (2019-01-01)

A Sweet Potion to Put Embryonic Stem Cells to Sleep
by: Kaushik D. Deb
Published: (2009-01-01)

Ethical Implications in the Use of Embryonic and Adult Neural Stem Cells
by: Rodrigo Ramos-Zúñiga, et al.
Published: (2012-01-01)

Retracted: Impact of Light and Temperature on Growth, Intracellular and Extracellular Pigment, and Lovastatin Yield by Monascus ruber in Synthetic Medium
by: Advances in Materials Science and Engineering
Published: (2024-01-01)

Amniotic-Fluid Stem Cells: Growth Dynamics and Differentiation Potential after a CD-117-Based Selection Procedure
by: S. Arnhold, et al.
Published: (2011-01-01)

Enigma of Retrotransposon Biology in Mammalian Early Embryos and Embryonic Stem Cells
by: Ying Yin, et al.
Published: (2018-01-01)

Dynamic Proteomic Analysis of Pancreatic Mesenchyme Reveals Novel Factors That Enhance Human Embryonic Stem Cell to Pancreatic Cell Differentiation
by: Holger A. Russ, et al.
Published: (2016-01-01)

Differential expression of CD175 and CA19-9 in pancreatic adenocarcinoma
by: Jane J. Cheng, et al.
Published: (2025-02-01)

Chromatin Structure and U2AF1-RS1 Gene Expression in Embryonic Stem Cells following RA-Induced Apoptosis
by: N. Andollo, et al.
Published: (2001-01-01)

Abnormal Decrease of Macrophage ALKBH5 Expression Causes Abnormal Polarization and Inhibits Osteoblast Differentiation
by: Junquan Weng, et al.
Published: (2023-01-01)