Insights into the protective effect of omega-3 nanoemulsion against colistin-induced nephrotoxicity in experimental rats: regulation of autophagy and necroptosis via AMPK/mTOR and RIPK1/RIPK3/MLKL signaling pathways

Insights into the protective effect of omega-3 nanoemulsion against colistin-induced nephrotoxicity in experimental rats: regulation of autophagy and necroptosis via AMPK/mTOR and RIPK1/RIPK3/MLKL signaling pathways

Colistin is considered one of the most effective antibiotics against gram-negative bacteria. However, nephrotoxicity is one of the dose-limiting factors in its treatment. This study aimed to evaluate the outcome of omega-3 nanoemulsion against colistin-induced nephrotoxicity and its possible underly...

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Bibliographic Details
Main Authors: Medhat Taha, Omer Abdelbagi, Tourki A. S. Baokbah, Rehab M. Bagadood, Naif A. Jalal, Rami Obaid, Nawal E. Al-Hazmi, Naeem F. Qusty
Format: Article
Language:English
Published: Taylor & Francis Group 2024-12-01
Series:Renal Failure
Subjects:
Omega-3 nanoemulsion
colistin
nephrotoxicity
oxidative stress
autophagy
necroptosis
Online Access:https://www.tandfonline.com/doi/10.1080/0886022X.2024.2429686
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https://www.tandfonline.com/doi/10.1080/0886022X.2024.2429686

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