Needle detection and localisation for robot‐assisted subretinal injection using deep learning

Abstract Subretinal injection is a complicated task for retinal surgeons to operate manually. In this paper we demonstrate a robust framework for needle detection and localisation in robot‐assisted subretinal injection using microscope‐integrated Optical Coherence Tomography with deep learning. Five...

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Main Authors: Mingchuan Zhou, Xiangyu Guo, Matthias Grimm, Elias Lochner, Zhongliang Jiang, Abouzar Eslami, Juan Ye, Nassir Navab, Alois Knoll, Mohammad Ali Nasseri
Format: Article
Language:English
Published: Wiley 2025-06-01
Series:CAAI Transactions on Intelligence Technology
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Online Access:https://doi.org/10.1049/cit2.12242
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author Mingchuan Zhou
Xiangyu Guo
Matthias Grimm
Elias Lochner
Zhongliang Jiang
Abouzar Eslami
Juan Ye
Nassir Navab
Alois Knoll
Mohammad Ali Nasseri
author_facet Mingchuan Zhou
Xiangyu Guo
Matthias Grimm
Elias Lochner
Zhongliang Jiang
Abouzar Eslami
Juan Ye
Nassir Navab
Alois Knoll
Mohammad Ali Nasseri
author_sort Mingchuan Zhou
collection DOAJ
description Abstract Subretinal injection is a complicated task for retinal surgeons to operate manually. In this paper we demonstrate a robust framework for needle detection and localisation in robot‐assisted subretinal injection using microscope‐integrated Optical Coherence Tomography with deep learning. Five convolutional neural networks with different architectures were evaluated. The main differences between the architectures are the amount of information they receive at the input layer. When evaluated on ex‐vivo pig eyes, the top performing network successfully detected all needles in the dataset and localised them with an Intersection over Union value of 0.55. The algorithm was evaluated by comparing the depth of the top and bottom edge of the predicted bounding box to the ground truth. This analysis showed that the top edge can be used to predict the depth of the needle with a maximum error of 8.5 μm.
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publishDate 2025-06-01
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spelling doaj-art-37b43dbad41a4d24976d3f623e76dfd62025-08-20T02:35:01ZengWileyCAAI Transactions on Intelligence Technology2468-23222025-06-0110370371510.1049/cit2.12242Needle detection and localisation for robot‐assisted subretinal injection using deep learningMingchuan Zhou0Xiangyu Guo1Matthias Grimm2Elias Lochner3Zhongliang Jiang4Abouzar Eslami5Juan Ye6Nassir Navab7Alois Knoll8Mohammad Ali Nasseri9Robotic Micro‐nano Manipulation Lab College of Biosystems Engineering and Food Science Zhejiang University Hangzhou ChinaRobotic Micro‐nano Manipulation Lab College of Biosystems Engineering and Food Science Zhejiang University Hangzhou ChinaSchool of Computation, Information and Technology Technische Universität München München GermanySchool of Computation, Information and Technology Technische Universität München München GermanySchool of Computation, Information and Technology Technische Universität München München GermanyCarl Zeiss Meditec AG München GermanyDepartment of Ophthalmology Second Affiliated Hospital of Zhejiang University College of Medicine Hangzhou ChinaSchool of Computation, Information and Technology Technische Universität München München GermanySchool of Computation, Information and Technology Technische Universität München München GermanyAugenklinik und Poliklinik Klinikum rechts der Isar der Technische Universität München München GermanyAbstract Subretinal injection is a complicated task for retinal surgeons to operate manually. In this paper we demonstrate a robust framework for needle detection and localisation in robot‐assisted subretinal injection using microscope‐integrated Optical Coherence Tomography with deep learning. Five convolutional neural networks with different architectures were evaluated. The main differences between the architectures are the amount of information they receive at the input layer. When evaluated on ex‐vivo pig eyes, the top performing network successfully detected all needles in the dataset and localised them with an Intersection over Union value of 0.55. The algorithm was evaluated by comparing the depth of the top and bottom edge of the predicted bounding box to the ground truth. This analysis showed that the top edge can be used to predict the depth of the needle with a maximum error of 8.5 μm.https://doi.org/10.1049/cit2.12242deep learningoptical coherence tomographyrobot‐assisted surgerysubretinal injection
spellingShingle Mingchuan Zhou
Xiangyu Guo
Matthias Grimm
Elias Lochner
Zhongliang Jiang
Abouzar Eslami
Juan Ye
Nassir Navab
Alois Knoll
Mohammad Ali Nasseri
Needle detection and localisation for robot‐assisted subretinal injection using deep learning
CAAI Transactions on Intelligence Technology
deep learning
optical coherence tomography
robot‐assisted surgery
subretinal injection
title Needle detection and localisation for robot‐assisted subretinal injection using deep learning
title_full Needle detection and localisation for robot‐assisted subretinal injection using deep learning
title_fullStr Needle detection and localisation for robot‐assisted subretinal injection using deep learning
title_full_unstemmed Needle detection and localisation for robot‐assisted subretinal injection using deep learning
title_short Needle detection and localisation for robot‐assisted subretinal injection using deep learning
title_sort needle detection and localisation for robot assisted subretinal injection using deep learning
topic deep learning
optical coherence tomography
robot‐assisted surgery
subretinal injection
url https://doi.org/10.1049/cit2.12242
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