Hypothermia protects against ventilator-induced lung injury by limiting IL-1β release and NETs formation

Hypothermia protects against ventilator-induced lung injury by limiting IL-1β release and NETs formation

Although mechanical ventilation is a critical intervention for acute respiratory distress syndrome (ARDS), it can trigger an IL-1β-associated complication known as ventilator-induced lung injury. In mice, we found that lipopolysaccharide (LPS) and high-volume ventilation, LPS-HVV, lead to hypoxemia...

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Bibliographic Details
Main Authors: Nobuyuki Nosaka, Vanessa Borges, Daisy Martinon, Timothy R Crother, Moshe Arditi, Kenichi Shimada
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2025-06-01
Series:eLife
Subjects:
macrophages
neutrophils
lung
acute
ventilator
ARDS
Online Access:https://elifesciences.org/articles/101990
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https://elifesciences.org/articles/101990

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