IRAK3 is upregulated in rheumatoid arthritis synovium and delays the onset of experimental arthritis

Tumour necrosis factor (TNF) is a potent inducer of endotoxin tolerance-associated molecules, such as interleukin-1 receptor-associated kinase 3 (IRAK3), and also a therapeutic target in inflammatory autoimmune diseases, as it upregulates the production of inflammatory mediators. The role of IRAK3 w...

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Bibliographic Details
Main Authors: Federica Borghese, Richard O. Williams, Felix I. L. Clanchy
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-04-01
Series:Frontiers in Immunology
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Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2025.1468341/full
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