Altered liver sinusoidal endothelial cells in MASLD and their evolution following lanifibranor treatment

Altered liver sinusoidal endothelial cells in MASLD and their evolution following lanifibranor treatment

Background & Aims: Data on changes in liver sinusoidal endothelial cells (LSECs) in patients with metabolic dysfunction-associated steatotic liver disease (MASLD) and their response to treatment are limited. This study aimed at determining (i) features associated with LSEC capillarisation in...

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Main Authors: Pierre-Emmanuel Rautou, Shivani Chotkoe, Louise Biquard, Guillaume Wettstein, Denise van der Graaff, Yao Liu, Joris De Man, Christophe Casteleyn, Sofie Thys, Winnok H. De Vos, Pierre Bedossa, Michael P. Cooreman, Martine Baudin, Jean-Louis Abitbol, Philippe Huot-Marchand, Lucile Dzen, Miguel Albuquerque, Pierre Broqua, Jean-Louis Junien, Luisa Vonghia, Manal F. Abdelmalek, Wilhelmus J. Kwanten, Valérie Paradis, Sven M. Francque
Format: Article
Language:English
Published: Elsevier 2025-06-01
Series:JHEP Reports
Subjects:
Intrahepatic vascular resistance
Vascular biology
LSECs
CD34
MASH
Liver fibrosis
Online Access:http://www.sciencedirect.com/science/article/pii/S2589555925000436
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