A compact and simple method of achieving differential transgene expression by exploiting translational readthrough

A compact and simple method of achieving differential transgene expression by exploiting translational readthrough

The development of multicistronic vectors enabling differential transgene expression is a goal of gene therapy and poses a significant engineering challenge. Current approaches rely on the insertion of long regulatory sequences that occupy valuable space in vectors, which have a finite and limited p...

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Bibliographic Details
Main Authors: James E Sillibourne, Giulia Agliardi, Matteo Righi, Katerina Smetanova, Grant Rowley, Simon Speller, Abigail Dolor, Katarina Lamb, Christopher Allen, Rajeev Karattil, Farhaan Parekh, Frederick Arce Vargas, Simon Thomas, Shaun Cordoba, Martin Pule
Format: Article
Language:English
Published: Taylor & Francis Group 2022-04-01
Series:BioTechniques
Subjects:
cancer
chimeric antigen receptor
differential transgene expression
immunotherapy
packaging limit
T cell
Online Access:https://www.future-science.com/doi/10.2144/btn-2021-0079
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