Targeting MDA‐MB‐231 Cancer Stem Cells With Temsirolimus in 3D Collagen/PGA/Na2SiO3‐Based Bone Model

Targeting MDA‐MB‐231 Cancer Stem Cells With Temsirolimus in 3D Collagen/PGA/Na2SiO3‐Based Bone Model

Abstract This study evaluated the efficacy of temsirolimus in a 3D model mimicking breast cancer stem cell (CSC) metastasis to bone. A composite material (collagen/PGA/Na₂SiO₃) is used to create a scaffold with bone marrow mesenchymal stem cells (BM‐MSCs) and human umbilical vein endothelial cells (...

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Bibliographic Details
Main Authors: Özlem Altundag‐Erdogan, Hayrullah Çetinkaya, Mustafa Özgür Öteyaka, Betül Çelebi‐Saltik
Format: Article
Language:English
Published: Wiley-VCH 2025-04-01
Series:Macromolecular Materials and Engineering
Subjects:
Bone
breast cancer stem cells
glutamic acid
metastasis
sodium metasilicate
Temsirolimus
Online Access:https://doi.org/10.1002/mame.202400360
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https://doi.org/10.1002/mame.202400360

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