Genetically determined serum urate levels and cardiovascular and other diseases in UK Biobank cohort: A phenome-wide mendelian randomization study.

Genetically determined serum urate levels and cardiovascular and other diseases in UK Biobank cohort: A phenome-wide mendelian randomization study.

<h4>Background</h4>The role of urate in cardiovascular diseases (CVDs) has been extensively investigated in observational studies; however, the extent of any causal effect remains unclear, making it difficult to evaluate its clinical relevance.<h4>Methods and findings</h4>A p...

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Main Authors: Xue Li, Xiangrui Meng, Yazhou He, Athina Spiliopoulou, Maria Timofeeva, Wei-Qi Wei, Aliya Gifford, Tian Yang, Tim Varley, Ioanna Tzoulaki, Peter Joshi, Joshua C Denny, Paul Mckeigue, Harry Campbell, Evropi Theodoratou
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2019-10-01
Series:PLoS Medicine
Online Access:https://journals.plos.org/plosmedicine/article/file?id=10.1371/journal.pmed.1002937&type=printable
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https://journals.plos.org/plosmedicine/article/file?id=10.1371/journal.pmed.1002937&type=printable

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