Neoadjuvant sintilimab and chemotherapy followed by transoral surgery for HPV-positive resectable oropharyngeal cancer: a single-arm, two-centre, phase 2 trialResearch in context

Neoadjuvant sintilimab and chemotherapy followed by transoral surgery for HPV-positive resectable oropharyngeal cancer: a single-arm, two-centre, phase 2 trialResearch in context

Summary: Background: Treatment deintensification, such as neoadjuvant immunochemotherapy and transoral surgery, has shown promise but remains under investigation in human papillomavirus-associated oropharyngeal squamous cell carcinoma (HPV+OPSCC). We aimed to explore the efficacy and safety of neoa...

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Main Authors: Shida Yan, Xing Zhang, Fengjiao Li, Ankui Yang, Hui Li, Wanming Hu, Qiaohong Lin, Xiyuan Li, Mingyuan Du, Jingtao Chen, Guodong Man, Jianwei Zhang, Xuemei Fang, Li Ning, Shiting Zhang, Lili Han, Yanmei Ma, Jun Wang, Shuwei Chen, Ming Song
Format: Article
Language:English
Published: Elsevier 2025-08-01
Series:EClinicalMedicine
Subjects:
Oropharyngeal cancer
HPV infection
Neoadjuvant therapy
Chemotherapy
Immunotherapy
Transoral surgery
Online Access:http://www.sciencedirect.com/science/article/pii/S2589537025003256
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