Safety and Efficiency of Ambulatory High-dose Methotrexate Administration among Hematological Malignancy Patients in a Tertiary Care Center

Safety and Efficiency of Ambulatory High-dose Methotrexate Administration among Hematological Malignancy Patients in a Tertiary Care Center

BACKGROUND: High-dose methotrexate (HDMTX) is commonly used in solid malignancies, such as osteosarcoma, and hematological malignancies, such as acute lymphoblastic leukemia and non-Hodgkin’s lymphoma. Urine alkalinization with intravenous sodium bicarbonate and calcium folinate to facilitate the cl...

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Main Authors: Maged Al-Ammari, Belal Mohammed Albtoosh, Alaa Eldein Yahia, Abdullah Alrajhi, Fouad Alnajjar, Imran Tailor, Mohammed S. Alnoamani, Nawal F. AlShehry, Mohammad Alwadi, Muhned Alhumaid, Mohammed A. Marei, Hassan Alshehri, Mubarak Salem Alghamdi, Kamal K. AlZahrani, Ibraheem Motabi
Format: Article
Language:English
Published: Wolters Kluwer Medknow Publications 2025-04-01
Series:Journal of Applied Hematology
Subjects:
adult
alkalization
antimetabolite
chemotherapy
clearance
efficient
leucovorin
lymphoma
oral
outpatient
Online Access:https://journals.lww.com/10.4103/joah.joah_3_25
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