Influence of Bisphosphonates on Alveolar Bone Loss around Osseointegrated Implants
Context: Bisphosphonates are extensively used drugs for the management of osteoporosis and other disorders affecting the bones. The stability and lifetime of osseointegrated dental implants may be influenced by their impact on bone metabolism. Materials and Methods: A randomized controlled trial was...
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2024-12-01
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| Series: | Journal of Pharmacy and Bioallied Sciences |
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| Online Access: | https://journals.lww.com/10.4103/jpbs.jpbs_1154_24 |
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| author | Vivek Ban A. Almudarris Smitha Sharan Prerna Kataria Pallavi Nanaiah Ravi Joshi Chaitanya S. Buddhikot Sheetal Acharya |
| author_facet | Vivek Ban A. Almudarris Smitha Sharan Prerna Kataria Pallavi Nanaiah Ravi Joshi Chaitanya S. Buddhikot Sheetal Acharya |
| author_sort | Vivek |
| collection | DOAJ |
| description | Context:
Bisphosphonates are extensively used drugs for the management of osteoporosis and other disorders affecting the bones. The stability and lifetime of osseointegrated dental implants may be influenced by their impact on bone metabolism.
Materials and Methods:
A randomized controlled trial was undertaken with a sample size of 60 individuals who were implanted with orally integrated dental implants. Study participants were split into two groups: Group A (n = 30) had bisphosphonate therapy for a minimum of 1 year before implant placement, while Group B (n = 30) did not have any bisphosphonate treatment. Cone beam computed tomography images were performed to quantify the alveolar bone levels surrounding the implants at three time points: baseline, 6 months, and 12 months after implantation.
Findings:
At the 6-month mark, Group A had an average bone loss of 0.8 mm with a standard deviation of 0.3 mm, but Group B had a bone loss of 1.2 mm with a standard deviation of 0.4 mm. At the 12-month mark, Group A experienced an average bone loss of 1.1 mm ± 0.5 mm, while Group B had a loss of 1.6 mm ± 0.6 mm. The substantial differences in bone loss between the groups were observed at both the 6-month (P < 0.05) and 12-month (P < 0.01) time points.
Conclusion:
Bisphosphonate treatment seems to decrease the atrophy of the alveolar bone surrounding osseointegrated dental implants, indicating a possible advantage in improving the durability and lifespan of the implants. |
| format | Article |
| id | doaj-art-3708a3c123dc4c2dafe30d7858d55667 |
| institution | Kabale University |
| issn | 0976-4879 0975-7406 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Journal of Pharmacy and Bioallied Sciences |
| spelling | doaj-art-3708a3c123dc4c2dafe30d7858d556672025-01-13T10:12:58ZengWolters Kluwer Medknow PublicationsJournal of Pharmacy and Bioallied Sciences0976-48790975-74062024-12-0116Suppl 4S3664S366610.4103/jpbs.jpbs_1154_24Influence of Bisphosphonates on Alveolar Bone Loss around Osseointegrated ImplantsVivekBan A. AlmudarrisSmitha SharanPrerna KatariaPallavi NanaiahRavi JoshiChaitanya S. BuddhikotSheetal AcharyaContext: Bisphosphonates are extensively used drugs for the management of osteoporosis and other disorders affecting the bones. The stability and lifetime of osseointegrated dental implants may be influenced by their impact on bone metabolism. Materials and Methods: A randomized controlled trial was undertaken with a sample size of 60 individuals who were implanted with orally integrated dental implants. Study participants were split into two groups: Group A (n = 30) had bisphosphonate therapy for a minimum of 1 year before implant placement, while Group B (n = 30) did not have any bisphosphonate treatment. Cone beam computed tomography images were performed to quantify the alveolar bone levels surrounding the implants at three time points: baseline, 6 months, and 12 months after implantation. Findings: At the 6-month mark, Group A had an average bone loss of 0.8 mm with a standard deviation of 0.3 mm, but Group B had a bone loss of 1.2 mm with a standard deviation of 0.4 mm. At the 12-month mark, Group A experienced an average bone loss of 1.1 mm ± 0.5 mm, while Group B had a loss of 1.6 mm ± 0.6 mm. The substantial differences in bone loss between the groups were observed at both the 6-month (P < 0.05) and 12-month (P < 0.01) time points. Conclusion: Bisphosphonate treatment seems to decrease the atrophy of the alveolar bone surrounding osseointegrated dental implants, indicating a possible advantage in improving the durability and lifespan of the implants.https://journals.lww.com/10.4103/jpbs.jpbs_1154_24alveolar bone lossbisphosphonatesosseointegration |
| spellingShingle | Vivek Ban A. Almudarris Smitha Sharan Prerna Kataria Pallavi Nanaiah Ravi Joshi Chaitanya S. Buddhikot Sheetal Acharya Influence of Bisphosphonates on Alveolar Bone Loss around Osseointegrated Implants Journal of Pharmacy and Bioallied Sciences alveolar bone loss bisphosphonates osseointegration |
| title | Influence of Bisphosphonates on Alveolar Bone Loss around Osseointegrated Implants |
| title_full | Influence of Bisphosphonates on Alveolar Bone Loss around Osseointegrated Implants |
| title_fullStr | Influence of Bisphosphonates on Alveolar Bone Loss around Osseointegrated Implants |
| title_full_unstemmed | Influence of Bisphosphonates on Alveolar Bone Loss around Osseointegrated Implants |
| title_short | Influence of Bisphosphonates on Alveolar Bone Loss around Osseointegrated Implants |
| title_sort | influence of bisphosphonates on alveolar bone loss around osseointegrated implants |
| topic | alveolar bone loss bisphosphonates osseointegration |
| url | https://journals.lww.com/10.4103/jpbs.jpbs_1154_24 |
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