Rational design of allosteric inhibitors targeting C797S mutant EGFR in NSCLC: an integrative in silico and in-vitro study

Rational design of allosteric inhibitors targeting C797S mutant EGFR in NSCLC: an integrative in silico and in-vitro study

BackgroundThe emergence of the C797S mutation in the epidermal growth factor receptor (EGFR) significantly limits the efficacy of covalent inhibitors in treating non-small cell lung cancer (NSCLC). This study aimed to design and evaluate novel allosteric inhibitors targeting the C797S mutant EGFR us...

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Bibliographic Details
Main Authors: Jian Wang, Feiyang Yuan, Mahadevi Kendre, Zhijin He, Shaowei Dong, Abhinandan Patil, Kausing Padvi
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-04-01
Series:Frontiers in Oncology
Subjects:
allosteric inhibitors
C797S mutant EGFR
non-small cell lung cancer
drug design
in-vitro assessment
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2025.1590779/full
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https://www.frontiersin.org/articles/10.3389/fonc.2025.1590779/full

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