The impact of aztreonam–clavulanic acid exposure on gene expression and mutant selection using a multidrug-resistant E. coli

The impact of aztreonam–clavulanic acid exposure on gene expression and mutant selection using a multidrug-resistant E. coli

ABSTRACT Multidrug-resistant Escherichia coli poses a significant threat to the healthcare system by causing treatment failure in infected patients. The use of a beta-lactam in combination with a beta-lactamase inhibitor has been shown to be an effective strategy to solve this problem. In vitro anti...

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Main Authors: Tongtong Lin, Jiayuan Zhang, Shuo Diao, Jinke Yan, Kexin Zhang, Jichao Cao, Junyi Huang, Yaohai Wang, Zhihua Lv, Xiaopeng Shen, Sherwin K. B. Sy, Michael Lynch, Hongan Long, Mingming Yu
Format: Article
Language:English
Published: American Society for Microbiology 2025-03-01
Series:Microbiology Spectrum
Subjects:
antibiotic combination
resistance mutations
evolution
mutagenesis
Online Access:https://journals.asm.org/doi/10.1128/spectrum.01782-24
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https://journals.asm.org/doi/10.1128/spectrum.01782-24

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