Immunological effects of CD19.CAR-T cell therapy in systemic sclerosis: an extended case study

Immunological effects of CD19.CAR-T cell therapy in systemic sclerosis: an extended case study

Abstract Objective The high potential of CD19.CAR-T cells to treat autoimmune diseases such as Systemic Sclerosis (SSc) supposedly relies on the disappearance of autoantibodies. Here we investigated effects of CAR-T cells on the innate immune system which is an important contributor to pathology in...

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Bibliographic Details
Main Authors: Maren Claus, Merle Freitag, Meike Ewald, Lea Rodon, Franca Deicher, Carsten Watzl, Philipp Kolb, Hanns-Martin Lorenz, Michael Schmitt, Wolfgang Merkt
Format: Article
Language:English
Published: BMC 2024-12-01
Series:Arthritis Research & Therapy
Subjects:
Systemic sclerosis
Pulmonary fibrosis
CAR-T cell therapy
NK cells
NKG2A
Fcγ receptor
Online Access:https://doi.org/10.1186/s13075-024-03451-1
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https://doi.org/10.1186/s13075-024-03451-1

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