Vedolizumab treatment across antiretroviral treatment interruption in chronic HIV infection: the HAVARTI protocol for a pilot dose-ranging clinical trial to assess safety, tolerance, immunological and virological activity

Introduction Continuous antiretroviral therapy (ART) suppresses HIV plasma viral load (pVL) to very low levels, which allows for some immune recovery. Discontinuation of ART leads to pVL rebound from reservoirs of persistence and latency, and progressive immunodeficiency. One promising but controver...

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Main Authors: Jonathan B Angel, Ashok Kumar, Michaeline McGuinty, Curtis L Cooper, Juthaporn Cowan, Paul A MacPherson, Sanjay Murthy, Richmond Sy, Michelle Dennehy, Nancy Tremblay, Siddappa N Byrareddy, D William Cameron
Format: Article
Language:English
Published: BMJ Publishing Group 2020-10-01
Series:BMJ Open
Online Access:https://bmjopen.bmj.com/content/10/10/e041359.full
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