Implications of the choice of method to identify major depressive disorder in large research cohorts

Implications of the choice of method to identify major depressive disorder in large research cohorts

Background: Clinical heterogeneity and variations in methods to identify major depressive disorder (MDD) across studies compromise replicability of research findings. This study evaluated potential implications of different MDD case definitions in a large biobank cohort. Methods: Among Mayo Clinic B...

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Main Authors: Jorge A. Sanchez-Ruiz, Nicolas A. Nuñez, Gregory D. Jenkins, Brandon J. Coombes, Lauren A. Lepow, Braja Gopal Patra, Ardesheer Talati, Mark Olfson, J. John Mann, Myrna M. Weissman, Jyotishman Pathak, Alexander Charney, Euijung Ryu, Joanna M. Biernacka
Format: Article
Language:English
Published: Elsevier 2025-09-01
Series:Journal of Mood and Anxiety Disorders
Subjects:
Mental health
Depressive disorder
Major
Electronic health records
Self report
Genetic risk score
Online Access:http://www.sciencedirect.com/science/article/pii/S2950004425000331
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