Adipsin improves diabetic hindlimb ischemia through SERPINE1 dependent angiogenesis

Adipsin improves diabetic hindlimb ischemia through SERPINE1 dependent angiogenesis

Abstract Background Adipsin (complement factor D, CFD), as the first described adipokine, is well-known for its regulatory effects in diabetic cardiovascular complications. However, its role in diabetic hind-limb ischemia was not clarified. This study aimed to evaluate the possible therapeutic effec...

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Main Authors: Xiaohua Zhang, Mengyuan Jiang, Xuebin Zhang, Yixuan Zuo, Huanle Zhang, Tingting Zhang, Liyu Yang, Jie Lin, Yan Zhang, Xinchun Dai, Wen Ge, Chuang Sun, Fang Yang, Jiye Zhang, Yue Liu, Yangyang Wang, Huanhuan Qiang, Xiaojie Yang, Dongdong Sun
Format: Article
Language:English
Published: BMC 2024-12-01
Series:Cardiovascular Diabetology
Subjects:
Diabetes
Hindlimb ischemia
Angiogenesis
Adipsin
Endothelial cells
Online Access:https://doi.org/10.1186/s12933-024-02526-2
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https://doi.org/10.1186/s12933-024-02526-2

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