Recognition and cleavage of human tRNA methyltransferase TRMT1 by the SARS-CoV-2 main protease

Recognition and cleavage of human tRNA methyltransferase TRMT1 by the SARS-CoV-2 main protease

The SARS-CoV-2 main protease (Mpro or Nsp5) is critical for production of viral proteins during infection and, like many viral proteases, also targets host proteins to subvert their cellular functions. Here, we show that the human tRNA methyltransferase TRMT1 is recognized and cleaved by SARS-CoV-2...

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Bibliographic Details
Main Authors: Angel D'Oliviera, Xuhang Dai, Saba Mottaghinia, Sophie Olson, Evan P Geissler, Lucie Etienne, Yingkai Zhang, Jeffrey S Mugridge
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2025-01-01
Series:eLife
Subjects:
host-virus interactions
RNA-protein interactions
tRNA modifications
protease
Online Access:https://elifesciences.org/articles/91168
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https://elifesciences.org/articles/91168

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