In-cell NMR reveals the first direct observation of endogenous interaction between HIV Tat protein and Tat RNA aptamer in human cells

In-cell NMR reveals the first direct observation of endogenous interaction between HIV Tat protein and Tat RNA aptamer in human cells

Abstract RNA–protein interactions lie at the basis of numerous regulatory and functional cellular biological processes, including transcriptional control, RNA processing, nuclear export, and viral replication. Despite their fundamental biological significance, direct structural investigation of RNA–...

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Bibliographic Details
Main Author: Omar Eladl
Format: Article
Language:English
Published: Nature Portfolio 2025-08-01
Series:Scientific Reports
Subjects:
RNA–protein interaction
HIV Tat protein
RNA aptamer
In-cell NMR
Confocal microscopy
Nuclear localization
Online Access:https://doi.org/10.1038/s41598-025-12791-0
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https://doi.org/10.1038/s41598-025-12791-0

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