AP5Z1 affects hepatocellular carcinoma growth and autophagy by regulating PTEN ubiquitination and modulating the PI3K/Akt/mTOR pathway

AP5Z1 affects hepatocellular carcinoma growth and autophagy by regulating PTEN ubiquitination and modulating the PI3K/Akt/mTOR pathway

Abstract Background Hepatocellular carcinoma (HCC) is a leading cause of cancer death worldwide, with high incidence and mortality rates, and the number of cases is expected to increase by 2030. Understanding the molecular mechanisms of HCC and identifying new therapeutic targets and biomarkers for...

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Bibliographic Details
Main Authors: Zhipeng Quan, Bo Peng, Kai Hu, Lixing Liang, Mingjiang Liu, Lijuan Liao, Shilian Chen, Jing Qin, Songqing He, Zeyuan Li
Format: Article
Language:English
Published: BMC 2025-05-01
Series:Journal of Translational Medicine
Subjects:
Hepatocellular carcinoma
AP5Z1
PTEN
TRIM21
Autophagy
Apoptosis
Online Access:https://doi.org/10.1186/s12967-025-06537-9
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https://doi.org/10.1186/s12967-025-06537-9

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