Rapamycin combined with anti-CD45RB mAb and IL-10 or with G-CSF induces tolerance in a stringent mouse model of islet transplantation.

Rapamycin combined with anti-CD45RB mAb and IL-10 or with G-CSF induces tolerance in a stringent mouse model of islet transplantation.

<h4>Background</h4>A large pool of preexisting alloreactive effector T cells can cause allogeneic graft rejection following transplantation. However, it is possible to induce transplant tolerance by altering the balance between effector and regulatory T (Treg) cells. Among the various Tr...

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Bibliographic Details
Main Authors: Nicola Gagliani, Silvia Gregori, Tatiana Jofra, Andrea Valle, Angela Stabilini, David M Rothstein, Mark Atkinson, Maria Grazia Roncarolo, Manuela Battaglia
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-01-01
Series:PLoS ONE
Online Access:https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0028434&type=printable
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https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0028434&type=printable

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