ILOBONE: A phase I/IIa randomized controlled trial to assess the safety and feasibility of local iloprost therapy for enhancing proximal humerus fracture healing– a pilot study design

ILOBONE: A phase I/IIa randomized controlled trial to assess the safety and feasibility of local iloprost therapy for enhancing proximal humerus fracture healing– a pilot study design

Abstract Background Proximal humerus fractures (PHFs) are the third most common fractures in elderly patients. Over 70% of PHFs in patients aged over 60 are displaced fractures, often necessitating surgical treatment. However, osteosynthesis is associated with a high rate of complications, highlight...

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Main Authors: Hisham Elazaly, Ioanna Maria Dimitriou, Tazio Maleitzke, Michael Dahne, Vera Jaecker, Sven Maerdian, Sascha Tafelski, Torsten Diekhoff, Tobias Lindner, Doruk Akgün, Anna-Maria Mielke, Alp Paksoy, Dominik Adl Amini, Elisa Marie Planatscher, Vincent Leopold, Susana González-Khatib, Paul Christoph Köhli, Marcel Niemann, Alexander Hildebrandt, Stephan Oehme, Yannick Palmowski, Melissa Paraskevaidis, Lukas Schönnagel, Sebastian Benedict Braun, Matthias Pumberger, Sebastian Hardt, Sigmar Stricker, Levent Akyüz, Gerald Grütz, Stefan Schaller, Luis Lauterbach, Maximilian Volcksdorff, Lukas Mödl, Martin Textor, Melanie Ort, Simon Reinke, Ulrich Stöckle, Carsten Perka, Georg N. Duda, Katharina Schmidt-Bleek, Sven Geissler, Tobias Winkler
Format: Article
Language:English
Published: BMC 2025-05-01
Series:Journal of Orthopaedic Surgery and Research
Subjects:
Proximal humerus fracture
Bone healing
Fracture repair
Iloprost
Ilomedin
PHILOS
Online Access:https://doi.org/10.1186/s13018-025-05865-2
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https://doi.org/10.1186/s13018-025-05865-2

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