Autophagy inhibition potentiates anti-cancer activity of Sunitinib in kidney cancer cells

Autophagy inhibition potentiates anti-cancer activity of Sunitinib in kidney cancer cells

Abstract Background Renal cell carcinoma (RCC), the most common solid tumor of the kidney, accounts for approximately 3% of all malignancies and has a higher incidence in Western countries. The current frontline treatment for metastatic RCC (mRCC) relies on immune checkpoint inhibitors (ICIs), alone...

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Main Authors: Simone Patergnani, Pietro Zampieri, Nicoletta Bianchi, Carmelo Ippolito, Roberta Gafà, Giovanni Lanza, Mariusz R. Wieckowski, Paolo Pinton, Gianluca Aguiari
Format: Article
Language:English
Published: BMC 2025-07-01
Series:Biology Direct
Subjects:
Renal cell carcinoma
Autophagy
Drug resistance
Sunitinib
Desmethylclomipramine
p53/p21 pathway
Online Access:https://doi.org/10.1186/s13062-025-00671-6
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https://doi.org/10.1186/s13062-025-00671-6

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