The dorsal column nuclei scale mechanical sensitivity in naive and neuropathic pain states

Summary: During pathological conditions, tactile stimuli can aberrantly engage nociceptive pathways leading to the perception of touch as pain, known as mechanical allodynia. The brain stem dorsal column nuclei integrate tactile inputs, yet their role in mediating tactile sensitivity and allodynia r...

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Main Authors: Aman Upadhyay, Mark A. Gradwell, Thomas J. Vajtay, James Conner, Arnab A. Sanyal, Chloe Azadegan, Komal R. Patel, Joshua K. Thackray, Manon Bohic, Fumiyasu Imai, Simon O. Ogundare, Yutaka Yoshida, Ishmail Abdus-Saboor, Eiman Azim, Victoria E. Abraira
Format: Article
Language:English
Published: Elsevier 2025-04-01
Series:Cell Reports
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Online Access:http://www.sciencedirect.com/science/article/pii/S2211124725003274
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