Engineered PD-L1 co-expression in PD-1 knockout and MAGE-C2-targeting TCR-T cells augments the cytotoxic efficacy toward target cancer cells

Engineered PD-L1 co-expression in PD-1 knockout and MAGE-C2-targeting TCR-T cells augments the cytotoxic efficacy toward target cancer cells

Abstract Expression of the PD-1 protein by tumor cells is relatively common and has been shown to exert proliferation-inhibitory effects across various tumor types, including T-cell malignancies, non-small cell lung cancer, and colon cancer. However, harnessing this tumor suppressor pathway is chall...

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Bibliographic Details
Main Authors: Fangxin Zhao, Xuan Zhang, Ying Tang, Hongxin Yang, Haiting Pan, Beibei Li, Riwen An, Wu Geyemuri, Chao Yang, Fang Wan, Jianqiang Wu
Format: Article
Language:English
Published: Nature Portfolio 2025-04-01
Series:Scientific Reports
Subjects:
PD-1/PD-L1
TCR-T
MAGE-C2
Cancer
Immunotherapy
Online Access:https://doi.org/10.1038/s41598-025-92209-z
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https://doi.org/10.1038/s41598-025-92209-z

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