Synthesis of the Pentasaccharide Unit of the <i>Pseudomonas aeruginosa</i> Exopolysaccharide Psl Conjugation with CRM197, and Evaluation of Antigenicity in a QS-21/Pam<sub>3</sub>CSK<sub>4</sub>-Liposomal Formulation

Synthesis of the Pentasaccharide Unit of the <i>Pseudomonas aeruginosa</i> Exopolysaccharide Psl Conjugation with CRM197, and Evaluation of Antigenicity in a QS-21/Pam<sub>3</sub>CSK<sub>4</sub>-Liposomal Formulation

Oligosaccharides and glycoconjugates play essential roles in various biological processes such as cellular recognition and signaling, and thus have attracted tremendous attention in the synthetic and biological communities over the past few decades. Contributing to this field, we have achieved the s...

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Bibliographic Details
Main Authors: Uzoamaka Clara Bokolo, Ravindika Dissanayake, Samir Ghosh, Shadia Nada, Babatunde S. Obadawo, Erin G. Prestwich, Katherine A. Wall, Steven J. Sucheck
Format: Article
Language:English
Published: MDPI AG 2025-04-01
Series:Molecules
Subjects:
<i>Pseudomonas aeruginosa</i>
Psl exopolysaccharide
carbohydrate vaccine
β-mannoside
CRM197
QS21
Online Access:https://www.mdpi.com/1420-3049/30/8/1720
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