Supramolecular drug-laden hydrogel based on structural tautomerization enhances drug delivery for rheumatoid arthritis treatment

Supramolecular drug-laden hydrogel based on structural tautomerization enhances drug delivery for rheumatoid arthritis treatment

Rheumatoid arthritis (RA) is a major autoimmune disease characterized by significant joint inflammation and bone destruction. Many first-line RA treatment drugs such as methotrexate (MTX) have limited solubility in major solvents and are difficult to be delivered to RA joints in a sustained manner....

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Bibliographic Details
Main Authors: Hao Li, Yuanning Lyu, Ruinan Wang, Hong Yu, Mingxin Lin, Zhuo Li, Yanlin Zhong, Puyi Sheng, Kunyu Zhang, Weiming Liao, Liming Bian
Format: Article
Language:English
Published: KeAi Communications Co., Ltd. 2025-11-01
Series:Bioactive Materials
Subjects:
Supramolecular hydrogel
Structural tautomerization
Drug delivery
Rheumatoid arthritis
Anti-inflammation
Bone remodeling
Online Access:http://www.sciencedirect.com/science/article/pii/S2452199X25003329
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http://www.sciencedirect.com/science/article/pii/S2452199X25003329

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