Methionine cycle in C. elegans serotonergic neurons regulates diet-dependent behaviour and longevity through neuron-gut signaling

Methionine cycle in C. elegans serotonergic neurons regulates diet-dependent behaviour and longevity through neuron-gut signaling

Abstract The folate and methionine cycles (Met-C) are regulated by vitamin B12 (B12), obtained exclusively from diet and microbiota. Met-C supports amino acid, nucleotide, and lipid biosynthesis and provides one-carbon moieties for methylation reactions. While B12 deficiency and polymorphisms in Met...

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Main Authors: Sabnam Sahin Rahman, Shreya Bhattacharjee, Simran Motwani, Govind Prakash, Rajat Ujjainiya, Shivani Chitkara, Tripti Nair, Rachamadugu Sai Keerthana, Shantanu Sengupta, Arnab Mukhopadhyay
Format: Article
Language:English
Published: Nature Portfolio 2025-06-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-60475-0
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https://doi.org/10.1038/s41467-025-60475-0

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