Regulation of cortical neurogenesis by MED13L via transcriptional priming and its implications for MED13L syndrome

Abstract Pathogenic variants in MED13L cause MED13L syndrome, a well-defined neurodevelopmental disorder characterized by motor deficits, intellectual disability, and language delay, yet its underlying developmental and molecular mechanisms remain largely elusive. To address this gap, we generated a...

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Main Authors: Jia Li, Yu-zhu Hao, Jia Cui, Xiao-xiao Cao, Nan Wu, Ji Ma, Shuang-yi Xie, Yi-Hsuan Pan, Xue-lian He, Yu-lan Zhao, Xiao-Bing Yuan
Format: Article
Language:English
Published: Nature Portfolio 2025-08-01
Series:Communications Biology
Online Access:https://doi.org/10.1038/s42003-025-08532-8
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