The Synthesis, Characterization, and Biological Evaluation of a Fluorenyl-Methoxycarbonyl-Containing Thioxo-Triazole-Bearing Dipeptide: Antioxidant, Antimicrobial, and BSA/DNA Binding Studies for Potential Therapeutic Applications in ROS Scavenging and Drug Transport

The Synthesis, Characterization, and Biological Evaluation of a Fluorenyl-Methoxycarbonyl-Containing Thioxo-Triazole-Bearing Dipeptide: Antioxidant, Antimicrobial, and BSA/DNA Binding Studies for Potential Therapeutic Applications in ROS Scavenging and Drug Transport

We report on the synthesis and characterization of a novel fluorenyl-methoxycarbonyl (Fmoc)-containing thioxo-triazole-bearing dipeptide <b>5</b>, evaluated for potential therapeutic applications. The compound was tested for its antioxidant and antimicrobial properties, demonstrating sig...

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Main Authors: Lala Stepanyan, Tatevik Sargsyan, Valentina Mittova, Zurab R. Tsetskhladze, Nino Motsonelidze, Ekaterine Gorgoshidze, Niccolò Nova, Monika Israyelyan, Hayarpi Simonyan, Franco Bisceglie, Lusine Sahakyan, Karapet Ghazaryan, Giovanni N. Roviello
Format: Article
Language:English
Published: MDPI AG 2025-06-01
Series:Biomolecules
Subjects:
fluorenyl-methoxycarbonyl
fmoc
thioxo-triazole
antioxidant properties
antimicrobial activity
bovine serum albumin
Online Access:https://www.mdpi.com/2218-273X/15/7/933
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