Nanoneedle‐Based Electroporation for Efficient Manufacturing of Human Primary Chimeric Antigen Receptor Regulatory T‐Cells

Nanoneedle‐Based Electroporation for Efficient Manufacturing of Human Primary Chimeric Antigen Receptor Regulatory T‐Cells

Abstract Regulatory T cells (Tregs) play a crucial role in moderating immune responses offering promising therapeutic options for autoimmune diseases and allograft rejection. Genetically engineering Tregs with chimeric antigen receptors (CARs) enhances their targeting specificity and efficacy. With...

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Main Authors: Ningjia Sun, Cong Wang, William Edwards, Yikai Wang, Xiangrong L. Lu, Chenlei Gu, Samuel McLennan, Panicos Shangaris, Peng Qi, Daniela Mastronicola, Cristiano Scottà, Giovanna Lombardi, Ciro Chiappini
Format: Article
Language:English
Published: Wiley 2025-06-01
Series:Advanced Science
Subjects:
CAR‐T
electroporation
nanoneedle
nanoscale electroporation
non‐viral transfection
regulatory T cells
Online Access:https://doi.org/10.1002/advs.202416066
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https://doi.org/10.1002/advs.202416066

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