Phenolic acids from Anisopus mannii modulates phosphofructokinase 1 to improve glycemic control in patients with type 2 diabetes: A double-blind, randomized, clinical trial

Phenolic acids from Anisopus mannii modulates phosphofructokinase 1 to improve glycemic control in patients with type 2 diabetes: A double-blind, randomized, clinical trial

Phenolic acid-rich fraction from Anisopus mannii (PhAM) contains abundance of ferulic acid, gallic acid, protocatechuic acid, and syringic acid. Among other glycolytic enzymes, in vitro, PhAM counteracted the binding of sodium orthovanadate to phosphofructokinase 1 (PFK-1), improving its activities....

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Main Authors: Peter U. Amadi, Justice O. Osuoha, Chidi N. Ekweogu, Suha J. Jarad, Esienanwan E. Efiong, Prince C. Odika, Chioma Ejiofor, Oluchi Aloy-Amadi, Govind S. Gill, Chiamaka W. Adumekwe, Ailun Gaowa, Dawei Zhang, Barbora de Courten, Emmanuel N. Agomuo
Format: Article
Language:English
Published: Elsevier 2025-02-01
Series:Pharmacological Research
Subjects:
Diabetes
Phosphofructokinase 1
Randomized trial
HbA1c
Anisopus mannii
Online Access:http://www.sciencedirect.com/science/article/pii/S1043661825000271
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