Targeting NGF but not VEGFR1 or BDNF signaling reduces endometriosis-associated pain in mice

Targeting NGF but not VEGFR1 or BDNF signaling reduces endometriosis-associated pain in mice

Introduction: Endometriosis is a chronic inflammatory disease that affects ∼10 % of women. A significant fraction of patients experience limited or no efficacy with current therapies. Tissue adjacent to endometriosis lesions often exhibits increased neurite and vascular density, suggesting that dise...

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Main Authors: Tiago H. Zaninelli, Victor Fattori, Olivia K. Heintz, Kristeena R. Wright, Philip R. Bennallack, Danielle Sim, Hussain Bukhari, Kathryn L. Terry, Allison F. Vitonis, Stacey A. Missmer, Avacir C. Andrello, Raymond M. Anchan, Stephen K. Godin, Dara Bree, Waldiceu A. Verri Jr., Michael S. Rogers
Format: Article
Language:English
Published: Elsevier 2025-07-01
Series:Journal of Advanced Research
Subjects:
Neurotrophins
BDNF
VEGF
VEGFR1
Visceral pain
Online Access:http://www.sciencedirect.com/science/article/pii/S2090123224003606
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