Self-assembled antioxidant enzyme-mimicking hydrogel: Targeting oxidative stress and macrophage organization for improving degenerated intervertebral discs

Self-assembled antioxidant enzyme-mimicking hydrogel: Targeting oxidative stress and macrophage organization for improving degenerated intervertebral discs

Intervertebral disc degeneration (IVDD) is a major contributor to lower back pain. At present, antioxidant therapy is regarded as one of the most promising strategies for treating IVDD, due to the critical role of reactive oxygen species (ROS) in its pathogenesis. Herein, we presented a self-assembl...

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Bibliographic Details
Main Authors: Yudong Fu, Hua Sun, Yongchao Jin, Shaohui Cheng, Yanyi Wu, Chen Liu, Lei Fan, Juqun Xi, Shixin Li, Liang Zhang
Format: Article
Language:English
Published: Elsevier 2025-04-01
Series:Materials Today Bio
Subjects:
Hydrogels
Enzyme-mimicking activities
Intervertebral disc degeneration
Inflammation
Macrophage polarization
Online Access:http://www.sciencedirect.com/science/article/pii/S2590006425001449
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