Remote ischemia precondition protects against renal IRI through apoptosis associated vesicles carrying MIF protein via modulating DUSP6/JNK signaling axis

Remote ischemia precondition protects against renal IRI through apoptosis associated vesicles carrying MIF protein via modulating DUSP6/JNK signaling axis

Abstract Background Remote ischemic preconditioning (rIPC) has been reported to protect against kidney ischemia-reperfusion injury (IRI) through the delivery of extracellular vesicles (EVs). Among these, apoptosis-induced compensatory proliferation signaling-related vesicles (ACPSVs) can transmit pr...

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Main Authors: Nieke Zhang, Zhicong Huang, Yi Xia, Shuchun Tao, Tiange Wu, Si Sun, Yongkun Zhu, Guiya Jiang, Xun Lu, Yue Gao, Fangfang Guo, Rui Cao, Shuqiu Chen, Lei Zhang, Xiangyu Zou, Ming Chen, Guangyuan Zhang
Format: Article
Language:English
Published: BMC 2025-06-01
Series:Journal of Nanobiotechnology
Subjects:
Remote ischemia precondition (rIPC)
Renal ischemia-reperfusion injury (IRI)
Apoptosis-induced compensatory proliferation signaling-related vesicles (ACPSVs)
Macrophage migration inhibitory factor (MIF)
DUSP6/JNK signaling axis
Online Access:https://doi.org/10.1186/s12951-025-03505-9
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https://doi.org/10.1186/s12951-025-03505-9

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