Acquisition of residency programs by T cells entering the human brain

Summary: T cell surveillance is mandatory for maintaining central nervous system (CNS) homeostasis, while aberrant accumulation is linked to neuroinflammation. To explore the residency programs acquired by T cells through different anatomical locations of the human brain, we isolated CD8+ and CD4+ T...

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Main Authors: Cheng-Chih Hsiao, Hendrik J. Engelenburg, Jasper Rip, Annet F. Wierenga-Wolf, Fabiënne van Puijfelik, Marvin M. van Luijn, Inge Huitinga, Jörg Hamann, Joost Smolders
Format: Article
Language:English
Published: Elsevier 2025-07-01
Series:Cell Reports
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Online Access:http://www.sciencedirect.com/science/article/pii/S2211124725007314
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