Effect of Tofacitinib on Hemostasis in Patients with Ulcerative Colitis: A Comparative Ex Vivo Study

Effect of Tofacitinib on Hemostasis in Patients with Ulcerative Colitis: A Comparative Ex Vivo Study

<b>Background:</b> Tofacitinib is effective for refractory ulcerative colitis (UC), a chronic inflammatory disease of the colonic mucosa. However, its use has been associated with an increased risk of thromboembolic events, prompting regulatory restrictions. Understanding the pathophysio...

Full description

Saved in:

Bibliographic Details
Main Authors:	Cristina Sánchez-Sánchez, Fabio Suarez-Trujillo, Cristina Ramírez, Irene Soleto, Jorge Mercado, Macarena Orejudo, Paula J. Martínez, Celia Rubio Collado, Mar Orts, María Jesús Rubio Franco, Antonio Planas, Natalia Acedo, Nora Butta, María Chaparro, Javier P. Gisbert, Montse Baldán-Martín
Format:	Article
Language:	English
Published:	MDPI AG 2025-04-01
Series:	Pharmaceuticals
Subjects:	tofacitinib ulcerative colitis platelet aggregation platelet activation thromboelastometry
Online Access:	https://www.mdpi.com/1424-8247/18/4/557
Tags:	Add Tag No Tags, Be the first to tag this record!

Similar Items

Platelet and Fibrinogen Contribution to Clot Strength in Premature Neonates with Sepsis
by: Dimitra Gialamprinou, et al.
Published: (2025-07-01)

Platelets and hemostasis
by: M. A. Panteleev, et al.
Published: (2014-09-01)

CORRELATION BETWEEN PARAMETERS OF HEMOSTASIS AND COURSE OF TUBERCULOSIS IN PULMONARY TUBERCULOSIS
by: A. A. Yatsenko, et al.
Published: (2016-03-01)

Laboratory profiles of patients hospitalized with COVID-19 pneumonia treated with tofacitinib or placebo: a post hoc analysis from the STOP-COVID trial
by: Patrícia Oliveira Guimarães, et al.
Published: (2024-11-01)

NEW APPROACHES TO PHARMACOTHERAPY OF RHEUMATOID ARTHRITIS: TOFACITINIB
by: E. L. Nasonov
Published: (2014-06-01)

Experimental and Mathematical Model of Platelet Hemostasis Kinetics
by: Bogdan Gerda, et al.
Published: (2025-05-01)

Effective Treatment of Livedoid Vasculopathy With Oral Tofacitinib
by: Parvin Mansouri, et al.
Published: (2025-06-01)

Management of Generalized Vitiligo in Adolescent with Tofacitinib: Clinical Case
by: Eduard T. Ambarchyan, et al.
Published: (2024-11-01)

Tofacitinib for managing granuloma formation after dermal filler injection: three case reports and literature review
by: Jieyi Wang, et al.
Published: (2024-12-01)

Efficacy and safety of tofacitinib for immune-mediated inflammatory rheumatic diseases (Part I)
by: E. L. Nasonov, et al.
Published: (2020-02-01)

THE PLACE OF TOFACITINIB IN THE TREATMENT STRATEGY OF RHEUMATOID ARTHRITIS
by: V. I. Mazurov, et al.
Published: (2018-05-01)

Effect of tofacitinib treatment on active MRI sacroiliitis in psoriatic arthritis patients
by: E. E. Gubar, et al.
Published: (2021-05-01)

Major mechanisms maintaining the regulation of hemostasis
by: Ramazan Çöl, et al.

Experience with tofacitinib in the treatment of resistant rheumatoid arthritis
by: A. R. Babaeva, et al.
Published: (2015-06-01)

Letter to the Editor Regarding the Article "Impact of Race on the Efficacy and Safety of Tofacitinib in Rheumatoid Arthritis: Post Hoc Analysis of Pooled Clinical Trials"
by: YanRan Qiu, et al.
Published: (2025-03-01)

PLATELET HEMOSTASIS DYNAMICS IN SIMVASTATINTREATED PATIENTS WITH ARTERIAL HYPERTENSION AND DYSLIPIDEMIA
by: I. N. Medvedev, et al.
Published: (2010-02-01)

DIAGNOSTICS OF HEMOSTASIS DISORDERS IN INFANTS
by: A. L. Mishchenko, et al.
Published: (2016-06-01)

Efficacy and safety of tofacitinib in an open-label, long-term extension study in patients with psoriatic arthritis who received adalimumab or tofacitinib in a Phase 3 randomized controlled study: a post hoc analysis
by: Dafna D. Gladman, et al.
Published: (2024-12-01)

Research progress on tofacitinib in the treatment of chronic actinic dermatitis
by: WU Hui, et al.
Published: (2024-12-01)

The concept of hemostasis disorders in severe leptospirosis
by: D. L. Moisova, et al.
Published: (2021-10-01)

Kindlin-3 phosphorylation is crucial for thrombosis and hemostasis in vivo
by: Elzbieta Pluskota, et al.
Published: (2025-03-01)

Refractory Segmental Hyaline Vasculitis Treated with Janus Kinase Inhibitor Tofacitinib: A Case Report
by: Zhang Y, et al.
Published: (2025-06-01)

The growing potential of tofacitinib in immune checkpoint inhibitor-induced colitis: identifying remaining puzzle pieces
by: Raffaele Pellegrino, et al.
Published: (2024-11-01)

Tofacitinib is a modern solution to the problem of resistant rheumatoid arthritis
by: I. V. Menshikova, et al.
Published: (2019-05-01)

Hemostasis in patients with primary myelofibrosis treated with ruxolitinib
by: O. G. Golovina, et al.
Published: (2024-11-01)

Assessment of vascular-platelet hemostasis in patients with hemorrhagic forms of erysipelas
by: R. I. Ratnikova, et al.
Published: (2014-09-01)

DIABETES MELLITUS AND CARDIOVASCULAR COMPLICATIONS: FOCUS ON HEMOSTASIS
by: G. G. Petrik, et al.
Published: (2014-03-01)

Application of the rotational thromboelastography/thromboelastometry for assessment of massive obstetric blood loss in a high risk group
by: D. R. Eremeeva, et al.
Published: (2020-04-01)

EFFICACY AND SAFETY OF TOFACITINIB FOR IMMUNEMEDIATED INFLAMMATORY RHEUMATIC DISEASES (PART II)
by: E. L. Nasonov, et al.
Published: (2020-04-01)

Relationships of dermatologic symptoms and quality of life in patients with psoriatic arthritis: analysis of two tofacitinib phase III studies
by: Peter C. Taylor, et al.
Published: (2022-07-01)

Immune thrombocytopenia at the patient with a cystadenoma of the ovaries (а clinical case)
by: N. A. Pluzhnikova, et al.
Published: (2020-04-01)

Vascular and platelet hemostasis and microcirculation in arterial hypertension patients
by: L. L. Kirichenko, et al.
Published: (2005-08-01)

The efficacy of narrowband ultraviolet B phototherapy combination with tofacitinib in the treatment of vitiligo: a randomized controlled trial
by: Xiaoyan Guo, et al.
Published: (2025-12-01)

Dissecting Cellulitis of the Scalp Successfully Treated with a Combination of Ixekizumab and Tofacitinib
by: Qiu M, et al.
Published: (2025-05-01)

EFFICACY AND SAFETY OF TOFACITINIB IN PATIENTS WITH PSORIATIC ARTHRITIS IN REAL CLINICAL PRACTICE
by: E. Yu. Loginova, et al.
Published: (2020-06-01)

Significant efficacy of tofacitinib from China in the treatment of alopecia areata: a case report
by: Yijia He, et al.
Published: (2025-04-01)

Polyarteritis nodosa is an unforeseen borderline paradoxical adverse reaction in a female patient with rheumatoid arthritis treated with tofacitinib
by: Yu. V. Muraviev, et al.
Published: (2019-09-01)

To study the role of tofacitinib and betamethasone pulse in the treatment of vitiligo at a tertiary care centre: an observational comparative study
by: Rashmi Singh, et al.
Published: (2024-01-01)

Successful treatment of a case of dupilumab-induced psoriasis and alopecia areata with tofacitinib
by: SUN Feifei, et al.
Published: (2025-06-01)

Discovery of Novel Tofacitinib–ADTOH Molecular Hybridization Derivatives for the Treatment of Ulcerative Colitis
by: Yi Mou, et al.
Published: (2025-03-01)