Diet-Intestinal Microbiota Axis in Osteoarthritis: A Possible Role
Intestinal microbiota is highly involved in host physiology and pathology through activity of the microbiome and its metabolic products. Osteoarthritis (OA) is a common form of arthritis characterized by articular cartilage destruction and osteophyte formation. Although various person-level risk fac...
Saved in:
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2016-01-01
|
| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/2016/3495173 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832559406715240448 |
|---|---|
| author | Yusheng Li Wei Luo Zhenhan Deng Guanghua Lei |
| author_facet | Yusheng Li Wei Luo Zhenhan Deng Guanghua Lei |
| author_sort | Yusheng Li |
| collection | DOAJ |
| description | Intestinal microbiota is highly involved in host physiology and pathology through activity of the microbiome and its metabolic products. Osteoarthritis (OA) is a common form of arthritis characterized by articular cartilage destruction and osteophyte formation. Although various person-level risk factors, such as age, sex, and obesity, have been proposed for the pathogenesis of OA, the underlying links between these person-level factors and OA are still enigmatic. Based on the current understanding in the crosstalk between intestinal microbiota and these risk factors, intestinal microbiota could be considered as a major hidden risk factor that provides a unifying mechanism to explain the involvement of these person-level risk factors in OA. |
| format | Article |
| id | doaj-art-35e431c4e78b4d53873ec0a3fc73b9ed |
| institution | Kabale University |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 2016-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-35e431c4e78b4d53873ec0a3fc73b9ed2025-02-03T01:30:07ZengWileyMediators of Inflammation0962-93511466-18612016-01-01201610.1155/2016/34951733495173Diet-Intestinal Microbiota Axis in Osteoarthritis: A Possible RoleYusheng Li0Wei Luo1Zhenhan Deng2Guanghua Lei3Department of Orthopaedics, Xiangya Hospital, Central South University, Changsha, Hunan 410078, ChinaDepartment of Orthopaedics, Xiangya Hospital, Central South University, Changsha, Hunan 410078, ChinaDepartment of Orthopaedics, Xiangya Hospital, Central South University, Changsha, Hunan 410078, ChinaDepartment of Orthopaedics, Xiangya Hospital, Central South University, Changsha, Hunan 410078, ChinaIntestinal microbiota is highly involved in host physiology and pathology through activity of the microbiome and its metabolic products. Osteoarthritis (OA) is a common form of arthritis characterized by articular cartilage destruction and osteophyte formation. Although various person-level risk factors, such as age, sex, and obesity, have been proposed for the pathogenesis of OA, the underlying links between these person-level factors and OA are still enigmatic. Based on the current understanding in the crosstalk between intestinal microbiota and these risk factors, intestinal microbiota could be considered as a major hidden risk factor that provides a unifying mechanism to explain the involvement of these person-level risk factors in OA.http://dx.doi.org/10.1155/2016/3495173 |
| spellingShingle | Yusheng Li Wei Luo Zhenhan Deng Guanghua Lei Diet-Intestinal Microbiota Axis in Osteoarthritis: A Possible Role Mediators of Inflammation |
| title | Diet-Intestinal Microbiota Axis in Osteoarthritis: A Possible Role |
| title_full | Diet-Intestinal Microbiota Axis in Osteoarthritis: A Possible Role |
| title_fullStr | Diet-Intestinal Microbiota Axis in Osteoarthritis: A Possible Role |
| title_full_unstemmed | Diet-Intestinal Microbiota Axis in Osteoarthritis: A Possible Role |
| title_short | Diet-Intestinal Microbiota Axis in Osteoarthritis: A Possible Role |
| title_sort | diet intestinal microbiota axis in osteoarthritis a possible role |
| url | http://dx.doi.org/10.1155/2016/3495173 |
| work_keys_str_mv | AT yushengli dietintestinalmicrobiotaaxisinosteoarthritisapossiblerole AT weiluo dietintestinalmicrobiotaaxisinosteoarthritisapossiblerole AT zhenhandeng dietintestinalmicrobiotaaxisinosteoarthritisapossiblerole AT guanghualei dietintestinalmicrobiotaaxisinosteoarthritisapossiblerole |