Exponential Clonal Expansion of 5-Fluorocytosine–Resistant Candida tropicalis and New Insights into Underlying Molecular Mechanisms

Exponential Clonal Expansion of 5-Fluorocytosine–Resistant Candida tropicalis and New Insights into Underlying Molecular Mechanisms

In 2022, we initiated systematic 5-fluorocytosine susceptibility testing of Candida spp. isolates in Denmark; we observed a bimodal MIC distribution in C. tropicalis, with MICs >16 mg/L in half the isolates. This study investigates the epidemiology and molecular mechanisms of 5-fluorocytosine re...

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Bibliographic Details
Main Authors: Nissrine Abou-Chakra, Karen Marie Thyssen Astvad, Jan Martinussen, Amalie Sofie Eilsø Munksgaard, Maiken Cavling Arendrup
Format: Article
Language:English
Published: Centers for Disease Control and Prevention 2025-05-01
Series:Emerging Infectious Diseases
Subjects:
antimicrobial resistance
fungi
flucytosine resistance
Candida tropicalis
clonal spread
emerging resistance
Online Access:https://wwwnc.cdc.gov/eid/article/31/5/24-1910_article
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https://wwwnc.cdc.gov/eid/article/31/5/24-1910_article

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