Microbial Colonization and Antibiotic Resistance Profiles in Chronic Wounds: A Comparative Study of Hidradenitis Suppurativa and Venous Ulcers
<b>Background/Objectives</b>: Chronic wounds, including hidradenitis suppurativa (HS) and venous ulcers (VU), are commonly associated with complex microbial communities that may influence wound healing and treatment outcomes. Understanding microbial diversity and antibiotic resistance pa...
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2025-01-01
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| author | Florica Sandru Elena Poenaru Smaranda Stoleru Andreea-Maria Radu Alexandra-Maria Roman Corina Ionescu Aurelian Zugravu Jafal Mugurel Nader Livia-Cristiana Băicoianu-Nițescu |
| author_facet | Florica Sandru Elena Poenaru Smaranda Stoleru Andreea-Maria Radu Alexandra-Maria Roman Corina Ionescu Aurelian Zugravu Jafal Mugurel Nader Livia-Cristiana Băicoianu-Nițescu |
| author_sort | Florica Sandru |
| collection | DOAJ |
| description | <b>Background/Objectives</b>: Chronic wounds, including hidradenitis suppurativa (HS) and venous ulcers (VU), are commonly associated with complex microbial communities that may influence wound healing and treatment outcomes. Understanding microbial diversity and antibiotic resistance patterns is essential in order to optimize therapeutic strategies. This study aimed to investigate the microbial populations and antibiotic resistance profiles in HS and VU patients, comparing the prevalence of common pathogens and their antimicrobial resistance profiles. <b>Methods</b>: We conducted a cross-sectional analysis that included a total of 112 individuals (24 with the diagnosis of hidradenitis suppurativa and 88 diagnosed with venous ulcer). Wound swabs were cultured to identify bacterial species, and antibiotic resistance was assessed using a standard panel of antibiotics. Prevalence rates of key pathogens, such as <i>Staphylococcus aureus</i>, <i>Pseudomonas aeruginosa</i>, and <i>Enterococcus faecalis</i>, were compared between the two groups. Resistance patterns were analyzed using statistical methods to identify significant differences. <b>Results</b>: <i>Staphylococcus aureus</i> was the most common pathogen in both groups (45.8% in HS; 38.6% in VU), with a notable prevalence of methicillin-resistant <i>S. aureus</i> (MRSA). <i>Pseudomonas aeruginosa</i> was exclusively identified in VU patients (27.3%), while beta-hemolytic <i>Streptococcus</i> and <i>Corynebacterium amycolatum</i> were identified in HS cases only. Antibiotic resistance was moderate, notably in <i>S. aureus</i> and <i>Proteus mirabilis</i>, while one case of multidrug-resistant <i>Pseudomonas aeruginosa</i> was identified. <b>Conclusions</b>: This study highlights the distinctive microbial profiles and antibiotic resistance patterns in HS and VU chronic wounds. The predominance of <i>S. aureus</i> in both groups underscores the need for targeted therapies, while the absence of <i>P. aeruginosa</i> in HS wounds and the higher prevalence of other species emphasizes wound-specific microbial variations. These findings underscore the importance of personalized treatment strategies and continuous surveillance of antimicrobial resistance. |
| format | Article |
| id | doaj-art-35d531de6e504f1c959da4d115374ff5 |
| institution | Kabale University |
| issn | 2079-6382 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | MDPI AG |
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| series | Antibiotics |
| spelling | doaj-art-35d531de6e504f1c959da4d115374ff52025-01-24T13:18:45ZengMDPI AGAntibiotics2079-63822025-01-011415310.3390/antibiotics14010053Microbial Colonization and Antibiotic Resistance Profiles in Chronic Wounds: A Comparative Study of Hidradenitis Suppurativa and Venous UlcersFlorica Sandru0Elena Poenaru1Smaranda Stoleru2Andreea-Maria Radu3Alexandra-Maria Roman4Corina Ionescu5Aurelian Zugravu6Jafal Mugurel Nader7Livia-Cristiana Băicoianu-Nițescu8Department of Dermatovenerology, “Carol Davila” University of Medicine and Pharmacy, 020021 Bucharest, RomaniaMedical Informatics and Biostatistics Discipline, “Carol Davila” University of Medicine and Pharmacy, 020021 Bucharest, RomaniaPharmacology and Pharmacotherapy Discipline, “Carol Davila” University of Medicine and Pharmacy, 020021 Bucharest, RomaniaDepartment of Dermatovenerology, “Carol Davila” University of Medicine and Pharmacy, 020021 Bucharest, RomaniaDepartment of Dermatovenerology, “Carol Davila” University of Medicine and Pharmacy, 020021 Bucharest, RomaniaDepartment of Dermatovenerology, “Carol Davila” University of Medicine and Pharmacy, 020021 Bucharest, RomaniaPharmacology and Pharmacotherapy Discipline, “Carol Davila” University of Medicine and Pharmacy, 020021 Bucharest, RomaniaAnesthesia and Intensive Therapy Discipline, “Carol Davila” University of Medicine and Pharmacy, 020021 Bucharest, RomaniaDepartment of Dermatovenerology, “Carol Davila” University of Medicine and Pharmacy, 020021 Bucharest, Romania<b>Background/Objectives</b>: Chronic wounds, including hidradenitis suppurativa (HS) and venous ulcers (VU), are commonly associated with complex microbial communities that may influence wound healing and treatment outcomes. Understanding microbial diversity and antibiotic resistance patterns is essential in order to optimize therapeutic strategies. This study aimed to investigate the microbial populations and antibiotic resistance profiles in HS and VU patients, comparing the prevalence of common pathogens and their antimicrobial resistance profiles. <b>Methods</b>: We conducted a cross-sectional analysis that included a total of 112 individuals (24 with the diagnosis of hidradenitis suppurativa and 88 diagnosed with venous ulcer). Wound swabs were cultured to identify bacterial species, and antibiotic resistance was assessed using a standard panel of antibiotics. Prevalence rates of key pathogens, such as <i>Staphylococcus aureus</i>, <i>Pseudomonas aeruginosa</i>, and <i>Enterococcus faecalis</i>, were compared between the two groups. Resistance patterns were analyzed using statistical methods to identify significant differences. <b>Results</b>: <i>Staphylococcus aureus</i> was the most common pathogen in both groups (45.8% in HS; 38.6% in VU), with a notable prevalence of methicillin-resistant <i>S. aureus</i> (MRSA). <i>Pseudomonas aeruginosa</i> was exclusively identified in VU patients (27.3%), while beta-hemolytic <i>Streptococcus</i> and <i>Corynebacterium amycolatum</i> were identified in HS cases only. Antibiotic resistance was moderate, notably in <i>S. aureus</i> and <i>Proteus mirabilis</i>, while one case of multidrug-resistant <i>Pseudomonas aeruginosa</i> was identified. <b>Conclusions</b>: This study highlights the distinctive microbial profiles and antibiotic resistance patterns in HS and VU chronic wounds. The predominance of <i>S. aureus</i> in both groups underscores the need for targeted therapies, while the absence of <i>P. aeruginosa</i> in HS wounds and the higher prevalence of other species emphasizes wound-specific microbial variations. These findings underscore the importance of personalized treatment strategies and continuous surveillance of antimicrobial resistance.https://www.mdpi.com/2079-6382/14/1/53hidradenitis suppurativavenous ulcerchronic woundwound colonizationantibiotic resistance<i>Staphylococcus aureus</i> |
| spellingShingle | Florica Sandru Elena Poenaru Smaranda Stoleru Andreea-Maria Radu Alexandra-Maria Roman Corina Ionescu Aurelian Zugravu Jafal Mugurel Nader Livia-Cristiana Băicoianu-Nițescu Microbial Colonization and Antibiotic Resistance Profiles in Chronic Wounds: A Comparative Study of Hidradenitis Suppurativa and Venous Ulcers Antibiotics hidradenitis suppurativa venous ulcer chronic wound wound colonization antibiotic resistance <i>Staphylococcus aureus</i> |
| title | Microbial Colonization and Antibiotic Resistance Profiles in Chronic Wounds: A Comparative Study of Hidradenitis Suppurativa and Venous Ulcers |
| title_full | Microbial Colonization and Antibiotic Resistance Profiles in Chronic Wounds: A Comparative Study of Hidradenitis Suppurativa and Venous Ulcers |
| title_fullStr | Microbial Colonization and Antibiotic Resistance Profiles in Chronic Wounds: A Comparative Study of Hidradenitis Suppurativa and Venous Ulcers |
| title_full_unstemmed | Microbial Colonization and Antibiotic Resistance Profiles in Chronic Wounds: A Comparative Study of Hidradenitis Suppurativa and Venous Ulcers |
| title_short | Microbial Colonization and Antibiotic Resistance Profiles in Chronic Wounds: A Comparative Study of Hidradenitis Suppurativa and Venous Ulcers |
| title_sort | microbial colonization and antibiotic resistance profiles in chronic wounds a comparative study of hidradenitis suppurativa and venous ulcers |
| topic | hidradenitis suppurativa venous ulcer chronic wound wound colonization antibiotic resistance <i>Staphylococcus aureus</i> |
| url | https://www.mdpi.com/2079-6382/14/1/53 |
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