Comparison of actionable alterations in cancers with kinase fusion, mutation, and copy number alteration.

Comparison of actionable alterations in cancers with kinase fusion, mutation, and copy number alteration.

Kinase-related gene fusion and point mutations play pivotal roles as drivers in cancer, necessitating optimized, targeted therapy against these alterations. The efficacy of molecularly targeted therapeutics varies depending on the specific alteration, with great success reported for such therapeutic...

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Main Authors: Shinsuke Suzuki, Toshiaki Akahane, Akihide Tanimoto, Michiyo Higashi, Ikumi Kitazono, Mari Kirishima, Masakazu Nishigaki, Toshiro Ikeda, Shuichi Kanemitsu, Junichi Nakazawa, Erina Akahane, Hiroshi Nishihara, Kimiharu Uozumi, Makoto Yoshimitsu, Kenji Ishitsuka, Shin-Ichi Ueno
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2025-01-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0305025
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https://doi.org/10.1371/journal.pone.0305025

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