Circadian Rhythm Disruption Exacerbates Autoimmune Uveitis: The Essential Role of PER1 in Treg Cell Metabolic Support for Stability and Function

Circadian Rhythm Disruption Exacerbates Autoimmune Uveitis: The Essential Role of PER1 in Treg Cell Metabolic Support for Stability and Function

Abstract Circadian rhythm plays a critical role in the progression of autoimmune diseases. While our previous study demonstrated the therapeutic effects of melatonin in experimental autoimmune uveitis, the involvement of circadian rhythm remained unclear. Using a light‐induced circadian rhythm disru...

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Bibliographic Details
Main Authors: Wenjie Zhu, Guanyu Chen, Zhiqiang Xiao, Minzhen Wang, Zhuang Li, Yuxun Shi, Xiaohui Luo, Zuoyi Li, Haixiang Huang, Xiaoqing Chen, Lingyi Liang, Dan Liang
Format: Article
Language:English
Published: Wiley 2025-03-01
Series:Advanced Science
Subjects:
autoimmune uveitis
cell metabolism
circadian rhythm
PER1
Treg
Online Access:https://doi.org/10.1002/advs.202400004
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https://doi.org/10.1002/advs.202400004

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