Abnormal brain functional activity and changes in c-Fos expression of propofol dependence in rats

Abnormal brain functional activity and changes in c-Fos expression of propofol dependence in rats

Propofol demonstrates dependence at subclinical anesthetic doses, however, the underlying neural mechanisms remain unclear. In this study, we established a self-administration model of propofol in Sprague-Dawley (SD) rats, used a combination of the amplitude of low-frequency fluctuation (ALFF) and r...

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Bibliographic Details
Main Authors: Zelin Zhuang, Zikai Huang, Lei Xie, Yuehua Huang, Xiaoyan Shi, Baowen Guo, Ziquan Xu, Yanbin Chen, Yuyin Cao, Yanmin Zheng, Rufeng Bai, Renhua Wu, Shuhua Ma
Format: Article
Language:English
Published: Elsevier 2025-10-01
Series:Brain Research Bulletin
Subjects:
Propofol dependence
Brain functional activity
Resting-state functional magnetic resonance imaging
C-Fos
Prefrontal cortex
Online Access:http://www.sciencedirect.com/science/article/pii/S0361923025003247
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