Genetic evidence from Mendelian randomization links CD40 levels to increased risk of estrogen receptor-positive breast cancer

Genetic evidence from Mendelian randomization links CD40 levels to increased risk of estrogen receptor-positive breast cancer

Abstract This study uses Mendelian randomization (MR) to investigate the causal roles of CD40 and CD40L in BC.Data from genome-wide association studies (GWAS) on BC (overall, ER-positive, and ER-negative subtypes) and CD40/CD40L levels were obtained from the IEU database. Causal associations were as...

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Bibliographic Details
Main Authors: Junyu Yi, Qingfeng Chen, Xiaoyi Liu, Yan Mao, Yongmei Wang, Meng Lv, Haibo Wang, Yuanyuan Wang
Format: Article
Language:English
Published: Nature Portfolio 2025-04-01
Series:Scientific Reports
Subjects:
Mendelian randomization CD40
CD40L
Breast cancer
ER-positive
Causal association
Online Access:https://doi.org/10.1038/s41598-025-99410-0
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https://doi.org/10.1038/s41598-025-99410-0

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